Global Audit of Treatment of
Refractory Status Epilepticus

Dear Colleague,

There is no consensus about the best form of therapy for refractory and super-refractory status epilepticus. As RCT are difficult to perform in this condition, we are appealing to doctors to take part to an online global audit. The participating doctors provide audit information about the treatment and outcome of cases prospectively encountered. Data collection is on very simple online forms which take only a few minutes to complete.

Aim: to discover what range of treatment are used, and their outcomes, in the treatment of cases of refractory status epilepticus around the world. The information will then form the basis of future research and guidelines.
Case definition: status epilepticus not responding to first-line therapy and requiring general anesthesia in an intensive care unit (ICU).
  • Adult and paediatric cases
  • All forms of status epilepticus
  • All aetiologies

This is an academically-driven exercise, with no external funding. Furthermore, as this is a simple audit of physician practice preferences, totally anonymised, ethics approval and patient consent are not usually required.

You can download further information and the audit procedure, so your IRBs may review it if necessary.

The study aim is to collect 1000 cases.

You can see some preliminary and interim results here.

The latest findings will be discussed at the next Status Epilepticus Colloquium in London in April 2015

To register for the audit, please enter your e-mail address below.

Once registered, you will receive monthly reminder to report new cases of status epilepticus. You can unregister your e-mail address any time.

All data will be entirely confidential. The e-mail address will not be handed to any third party. All communications for the audit team will be made by e-mail.

If you need help you can refer to your local member of the international steering committee or contact us.


Yours sincerely,

Dr. Monica Ferlisi Italy
Dr. Sara Hocker US
Prof. Simon Shorvon UK
Prof. Eugen Trinka Austria

(Audit Coordinators)

Global Audit of Treatment of Refractory and Super-Refractory Status Epilepticus